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ACACA MTOR (1 - 1 of 1)
PMID: 23414799
Fluorinated N,N'-diarylureas as AMPK activators.
... inhibiting acetyl-CoA carboxylase (ACC) and regulates mTOR signaling by ...   (details)

ACACA MTOR

Type:  regulation
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Theme:  mTOR-signaling   (MLST8   RPTOR   MTOR )

PMID: 23414799

Fluorinated N,N'-diarylureas as AMPK activators.
Source

Bioorganic & medicinal chemistry letters (3/15/2013)

Abstract

Fluorinated N, N'-diarylureas as AMPK activators. Adenosine monophosphate-activated kinase (AMPK) plays a central role in regulating energy homeostasis in eukaryotic cells. AMPK also regulates lipid synthesis by inhibiting acetyl-CoA carboxylase (ACC) and regulates mTOR signaling by activating TSC2. Due to its important roles in cell metabolism, AMPK is an attractive target for metabolic diseases, such as type II diabetes and obesity. AMPK activators, such as metformin, that are used for diabetes treatment are also effective anticancer agents. However, the efficacies of many known AMPK activators are relatively low. For example, metformin activates AMPK at millimolar levels. In this study, we identified a novel family of AMPK activators, namely fluorinated N, N'-diarylureas, that activate AMPK at 1-3┬ÁM concentrations. These novel agents strongly inhibit the proliferation of colon cancer cells. We studied the potential mechanisms of these agents, performed a structure-activity relationship (SAR) study and identified several fluorinated N, N'-diarylureas as potent AMPK activators.